Prostate Manager Saw Palmetto 5000mg 60 Veggie Capsules

Saw palmetto (Serenoa repens) is the fruit of a palm native to the southeastern United States, and its fat-soluble extract, rich in fatty acids and plant sterols, is used as an ingredient for middle-aged men. Lycopene is the carotenoid that gives tomatoes their red colour and is a potent antioxidant.

Laboratory studies indicate that the fatty acids (lauric acid, oleic acid, etc.) and beta-sitosterol in saw palmetto extract inhibit 5-alpha reductase, the enzyme that converts testosterone to dihydrotestosterone (DHT), and research has also looked at pathways related to inflammatory mediators and smooth muscle tension. Lycopene is a carotenoid with a high capacity to quench singlet oxygen and has been studied in relation to markers of oxidative damage to lipids and DNA and vascular endothelial function.

1. A Cochrane systematic review (2023) pooling randomised controlled studies in men with urinary discomfort assessed saw palmetto alone as making little or no difference to urinary symptom scores versus placebo. It should be considered an ingredient with mixed evidence.
2. In a 12-week randomised, double-blind, placebo-controlled study of 68 Japanese people aged 50 and over who experienced discomfort from frequent urination without any diagnosis (320 mg/day), daytime urinary frequency discomfort scores and daytime voiding frequency in a voiding diary improved versus placebo.
3. In an 8-week randomised, placebo-controlled study of 126 healthy men, the group taking lycopene 15 mg/day showed a dose-dependent rise in serum lycopene, increased antioxidant enzyme (SOD) activity, reduced lymphocyte DNA damage markers and improved vascular endothelial function markers (RH-PAT).

1. meta-analysisFranco JV et al. Serenoa repens for the treatment of lower urinary tract symptoms due to benign prostatic enlargement Cochrane Database Syst Rev. 2023. PMID 37345871
2. RCTKimura M et al. Beneficial effects of saw palmetto (Serenoa repens) fruit extract on the urinary symptoms of healthy Japanese adults with possible lower urinary tract symptoms: A randomized, double-blind, placebo-controlled study Nutr Health. 2025. PMID 39042923
3. RCTKim JY et al. Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men Atherosclerosis. 2011. PMID 21194693

A plant polyphenol ingredient made by water extraction of the bark of New Zealand radiata pine (Pinus radiata). On a dry powder basis it contains over 80% proanthocyanidins, along with taxifolin (1–2%) and other flavonoids and phenolic acids.

Its main constituents, proanthocyanidins (oligomers of linked catechin and epicatechin units), are known to scavenge free radicals directly and regenerate vitamin C, supporting the body's antioxidant network. Studies have looked at its relationship to the nitric oxide (NO) production environment in vascular endothelial cells, and cell experiments observed reduced expression of endothelial adhesion molecules and reduced monocyte migration in response to TNF-α stimulation. Test-tube studies have also reported lowered activity of carbohydrate-digesting enzymes (α-amylase, α-glucosidase), so its relationship to post-meal metabolic responses is being studied. These antioxidant and vascular mechanisms form the background for research on blood flow to the brain and cognitive function markers.

1. In a 5-week double-blind controlled study of 42 men aged 50–65 with a body mass index of 25 or more, the Enzogenol + vitamin C group showed faster response times on spatial working memory and immediate recognition tasks, while the vitamin C-only group showed no change. There were no changes in blood safety markers.
2. In a study randomising 44 adult smokers to Enzogenol 480 mg + vitamin C or vitamin C alone for 12 weeks, vascular dilation response (FMD) improved similarly in both groups, but the protein oxidation marker (protein carbonyl) was significantly lower in the Enzogenol group, and lower fibrinogen levels were observed in heavier smokers.
3. In a crossover study in which 25 healthy adults took placebo and Enzogenol 50 mg and 400 mg before oral glucose tolerance tests, people with a single-peak glucose curve showed a lower post-meal incremental glucose area (iAUC) and lower peak glucose than with placebo.
4. Composition and toxicity studies of the ingredient reported no abnormal findings with repeated dosing in animals, and no adverse changes in liver or kidney function or haematological markers in humans taking 480 mg/day for 6 months or 960 mg/day for 5 weeks.

1. RCTPipingas A et al. Improved cognitive performance after dietary supplementation with a Pinus radiata bark extract formulation. Phytother Res. 2008. PMID 18683195
2. RCTYoung JM et al. Comparative effects of enzogenol and vitamin C supplementation versus vitamin C alone on endothelial function and biochemical markers of oxidative stress and inflammation in chronic smokers. Free Radic Res. 2006. PMID 16298763
3. clinical studyLim WXJ et al. An Acute, Placebo-Controlled, Single-Blind, Crossover, Dose-Response, Exploratory Study to Assess the Effects of New Zealand Pine Bark Extract (Enzogenol(®)) on Glycaemic Responses in Healthy Participants. Nutrients. 2020. PMID 32075228
4. clinical studyFrevel MA et al. Production, composition and toxicology studies of Enzogenol® Pinus radiata bark extract. Food Chem Toxicol. 2012. PMID 22982471